Aquaporin > Technology > Biomimetic membranes

NEW SEPARATION TECHNOLOGY TOOLS WITH ANCIENT ROOTS

Nature provides an excellent palette of highly effective membranes capable of highly selective transport of a large number of molecular species. It is therefore striking that historically the membrane industry has developed synthetic separation membrane processes in a very different way.

Traditional separation membranes are mostly dense polymeric films where advanced chemistry is used to control the surface properties of the films produced. A wide range of polymers and production techniques are used resulting in a great diversity in structure and function of separation membranes tailored to a wide variety of applications. Separation is usually described in terms of pore/solute size, pore/solute charge and dielectric effects, coupled with diffusion or convective flow. Occasionally, more complex partitioning and transport mechanisms are used, however, most synthetic membranes may be broadly described as polymer sheets containing micron to nanometer sized holes.

This is in stark contrast to the bewildering complexity of biological membranes. 30 % of the human genome codes for membrane proteins, and a typical mammalian cell membrane hosts several hundred lipid types. Despite dramatic progress over the last decades in our understanding of the molecular basis for biological membrane transport, this complexity remains a major obstacle in our molecular understanding of how living cells maintain their integrity and perform their function.

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One way leading to a better understanding of membranes and membrane transport is to focus on a few of its components and features. This understanding is crucial if we want to exploit – or mimic – nature’s tremendous capability for selective membrane transport. The term Biomimetic Membranes denotes the common denominator for such endeavors.

In the development of biomimetic membranes, it is important to know the intrinsic properties of the molecules (lipid- or polymer-based) forming the membrane. Also important are the properties of interaction: the stability against mechanical perturbations, the rate of regeneration (self-healing), the ease with which functional proteins can be incorporated and, once incorporated, how proteins maintain stable function. Perhaps the most challenging part of biomimetic membrane development for filtration purposes is to understand the interaction between the membrane and its support – as the support also is porous so it can support mass transport across the membrane.

The research area of aquaporin-based membranes has developed significantly over the last decade and several designs have been proposed. Today the technology is commercially available in the form of Aquaporin Inside™ membranes for both forward osmosis (FO) and reverse osmosis (RO) applications.

References: 

  • Tang, C., Wang, Z., Petrinic, I., Fane, A.G., and Hélix-Nielsen, C. Biomimetic aquaporin membranes coming of age. Desalination 368, 89-105, 2015